Glucose Variability

Glucose Variability

The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia. Variability of glycemia in ambulatory conditions defined as the deviation from steady state is a phenome...

Glucose variability and complications.

In this issue of the Diabetes Care, Kilpatrick et al. (1) report their analysis of the large Diabetes Control and Complications Trial (DCCT) database on the relationship between glucose variability and relative risk of developing microangiopathic complications in type 1 diabetes. They find that glucose variability (intraday blood glucose excursions) does not play a role and conclude that only e...

Glycemic Variability Percentage: A Novel Method for Assessing Glycemic Variability from Continuous Glucose Monitor Data

BACKGROUND High levels of glycemic variability are still observed in most patients with diabetes with severe insulin deficiency. Glycemic variability may be an important risk factor for acute and chronic complications. Despite its clinical importance, there is no consensus on the optimum method for characterizing glycemic variability. METHOD We developed a simple new metric, the glycemic vari...

Glycemic Variability and Ambulatory Glucose Profile in Indian Diabetics.

Characterizing blood glucose variability using new metrics with continuous glucose monitoring data.

OBJECTIVE Glycemic variability contributes to oxidative stress, which has been linked to the pathogenesis of the long-term complications of diabetes. Currently, the best metric for assessing glycemic variability is mean amplitude of glycemic excursion (MAGE); however, MAGE is not in routine clinical use. A glycemic variability metric in routine clinical use could potentially be an important mea...